MRD tests like RaDaR have shown utility across the cancer care continuum for patients with lung cancer.
RaDaR applicability in lung cancer
- Risk stratification: How likely is it for your patient’s tumor to recur? Positive ctDNA result can mean your patient is at high risk of recurrence
- Surveillance: Regular monitoring with ctDNA may give you an indication of tumor recurrence before standard of care (SOC) imaging results
ctDNA from lung cancers, particularly when in early stage, are found at very low levels in the blood, making a highly sensitive test like RaDaR an ideal choice for MRD testing in lung cancer.
Clinical support for ctDNA surveillance in lung cancer
RISK ASSESSMENT AND SURVEILLANCE IN STAGE I-III LUNG CANCER
In operable stages I-III non-small cell lung cancer (NSCLC), there is a significant risk of relapse after a surgery with curative intent.
The LUCID study utilized the RaDaR MRD test over the course of patient treatment.1 The study found that patients with ctDNA detected at the postsurgical, or “landmark”, timepoint had a 14.8-fold higher risk of recurrence of their primary tumor compared to patients who were found to be ctDNA-negative.
The same study was also used to monitor patients' disease, looking for early signs of disease recurrence. RaDaR detected recurrent disease a median of nearly 7 months ahead of imaging.
Reference: 1. Gale D, et al. Ann Oncol. 2022;33(5):500-510.
RaDaR has been carefully designed to help you detect tumor DNA in the blood with exceptional sensitivity and specificity
- Increased accuracy with a tumor-informed, personalized panel design: RaDaR sequencing assays monitor up to 48 tumor-specific mutations, unique to each patient’s tumor, to help detect circulating tumor DNA (ctDNA)
- Earlier detection with high sensitivity: RaDaR can detect extremely low levels of ctDNA in the blood, with a demonstrated LoD95 = 0.001% VAF. This can give additional time for important treatment management decisions
- Fewer false positives with high specificity: RaDaR has a demonstrated analytical specificity of 100% in validation studies, giving you the confidence that comes from having more reliable results
NeoGenomics has been supporting oncologists and pathologists in their goal to provide patients with the best care possible since 2002.
LoD95 = limit of detection, working at a confidence of 95%; VAF = variant allele fraction.
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